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DANGER Gregoire

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Assistant Professor - Aix Marseille University

Secretary of the French Society of Exobiology (Société Française d’Exobiologie (SFE))
Member of the French Society of Exobiology (Société Française d’Exobiologie (SFE))
Member of the French Chemical Society (Société Chimique de France (SCF))
Member of the French Society of Astronomy and Astrophysic (Société Française d’Astronomie et d’Astrophysique (SF2A))
Member of the International Society for the Study of the Origin of Life and Astrobiology (ISSOL)

Centre saint Jérôme - 252
Office phone : + 33 4 91 28 82 85
Fax : + 33 4 91 28 91 94
E-mail

Research Topics
Areas of expertise
Research Experience
Supervision
Funds and Awards
Conference Organization
Bibliography
Conferences

Research Topics

The FAPCOME Project : From Astrochemistry to Prebiotic Chemistry : Organic Matter Evolution.

Astrochemistry : Evolution of organic matter from dense molecular clouds to planetary systems.

*Chemical reactivity at low temperature and high vacuum (RING project)  : Research on chemical pathways for the formation of molecules in astrophysical environments from analogs of interstellar or cometary ices.

*Residue Analysis from the Heating of Interstellar Ice Analogs (RAHIIA project) :  : Understanding the composition and the evolution of organic matter in meteorites and comets from analogs.

*Volatile Analysis from the Heating of Interstellar Ice Analogs (VAHIIA project, ANR-12-JS08-0001-01-VAHIIA) : Study of volatile organic compounds coming from the warming of interstellar/cometary ice analogs. Reactivity and identification.

*Space mission VITRINE (CNES) : Member of the Scientific Team. Development of cryogenic systems for ice analogs in space.

Prebiotic Chemistry : Prebiotic Environment for Peptide Synthesis and Evolution (PEPSE project - ANR-14-CE33-0020-02 PeptiSystems).

*Research of new pathways for oligopeptide formation in prebiotic conditions : : Development of a chemical system allowing the formation of oligopeptides in prebiotic conditions.

*Study on the physico-chemical selectivity during oligopeptide formation :  : Determine in which condition a chemical system allowing oligopeptide formation could lead to the emergence of specific physico-chemical properties such as auto-catalysis.

Areas of expertise

- Separation Methods  :
Capillary electrophoresis : Chiral or achiral separation of biomolecules in free medium or in presence of grafted polymers. Stacking using electric field amplification or using isotachophoresis. Electro-osmotic flow modulation using multilayers of polymers and polyelectrolytes.
Microfluidic systems : Chiral or achiral separation of amino acids using temperature gradient electrophoresis or gradient elution isotachophoresis.
Gas phase chromatography : chiral or achiral separation of amino acids.
Mass spectrometry : QMS and FT-orbirtap.

- Spectroscopic analysis  : RMN (1H, 13C, 1H-13C, 1H-1H), UV-visible, IR-TF.

- Analytical Developments  : Modification of commercial systems for application to specific experimental systems (Examples VAHIIA and RAHIIA systems).

- Chemical synthesis  : peptide synthesis step by step, in solid or homogeneous phase. Peptides and amino acids derivatives. UV irradiation under high vacuum and low temperature. Thermal reactivity at low temperature and low pressure.

Research Experience

2009/11/01- today
Associate Professor at the Aix-Marseille University, centre de Saint Jérôme, laboratory of Physique des Interactions Ioniques et Moléculaires UMR-CNRS 7345, research group « Spectrometrie et Dynamique Moléculaire », Marseille.

2008/09-2009/09
Post-doctorate position : ”Developments in capillary electrophoresis : bacterial screening, analysis and characterization of grafted dendrimers of lysine”. Funds from the French government and performed at the Institut des Biomolécules Max Mousseron UMR 5247, research group Dynamique des Systèmes Biomoléculaires Complexes, University of Montpellier 2, France. Supervisor : Pr Hervé Cottet et Dr Jean-Christophe Rossi. Collaboration with COLCOM industry.

2007/11-2008/08
Post-doctorate position : ”Origin of prebiotic organic matter at the surface of telluric planets”. Funds from the “Centre National d’Etudes Spatiales” (CNES) and made at the “Institut d’Astrophysique Spatial” (IAS), Orsay, France. Supervisor : Dr Louis d’Hendecourt.

2006/11-10/2007
Post-doctorate position : “Development of micro-fluidic systems for ultrasensitive
in situ Analysis of Biomarkers”. Funds from the “National Aeronautics and Space Administration” (NASA) and made at the “National Institute of Standards and Technology” (NIST), Gaithersburg MD, United State of America. Supervisor : Dr David Ross. Collaboration with Dr Richard Mathies (University of Berkley).

2002/10-2006/05
Doctorat : " Des N-carboxyanhydrides d’acides [alpha]-aminés (NCA) aux peptides : PhD " From N-carboxyanhydrides of [alpha]-amino acids (NCA) to peptides : new reactions of prebiotic interest and applications ; stacking and electro-osmotic flow control for the analysis of peptides with capillary electrophoresis." Supervisor : Pr J.Taillades ; physico-organic chemistry advisor : Dr R.Pascal et Dr L.Boiteau ; analytical chemistry advisor : Dr H.Cottet. Laboratoire OMEMF, UMR 5073, research group DSBC, University of Montpellier II, France. May 18th 2006.
Jury : Dr L.Boiteau, Dr H.Cottet, Pr J.Martinez, Dr J-C.Plaquevent, Pr J.Taillades et Pr M.Taverna.

Supervision

06/2015-06/2016 Dr. Ninette Abou Mrad (Belles-Limeul) post-doc funded by the Fondation Université d’Aix-Marseille VAHIIA Project.

11/2013-11/2016 Aurélien Fresneau PhD student with a CNES/région PACA grant.

06/2013-06/2015 Dr. Ninette Abou Mrad (Belles-Limeul) post-doc on ANR VAHIIA.

Since 2009 4 internships of undergraduates and master students.

Funds and Awards

06/2015-06/2016 Post-doc funded by the Fondation de l’Université d’Aix-Marseille projet VAHIIA, Dr Ninette Abou Mrad (Belles Limeul).

10/2014-10/2019 Agence Nationale de la Recherche "Défis de tous les Savoirs" (420k€). Funding for the project « Energetic processes driving potential peptide protometabolisms at the origin of living systems - PeptiSystems » (ANR-PeptiSystems). PI R. Pascal (IBMM), co-PI G.Danger (PIIM).

09/2014-09/2015 Delegation funded by CNRS 2014/09/01 to 2015/08/31.

2014-2015 Programme National de Planétologie (6.5k€). Funding for the project "Residue Analyses from the Heating of Interstellar Ice Analogs - RAHIIA". PI.

11/2013-11/2016 PhD grant funded by CNES/Région PACA RAHIIA project, Aurélien Fresneau.

06/2013-06/2015 Post-doc grant funded by the Agence Nationale de la Recherche JCJC VAHIIA project, Dr Ninette Abou Mrad (Belles Limeul).

09/2013-09/2014 Delegation funded by CNRS 2013/09/01 to 2014/08/31.

01/01/2013-31/12/2015 Agence Nationale de la Recherche JCJC (247.5k€). Funding for the project « Volatile Analyses from the Heating of Interstellar Ice Analogs - VAHIIA » (ANR-12-JS08-0001-01-VAHIIA). PI.

2012-2013 Centre National d’Etude Spatiale (19k€). Project « simulations expérimentales pour l’analyse des données issues de missions spatiales : evolution d’analogues des glaces interstellaires ou cométaires jusqu’à la formation de composés organiques refractaires ». co-PI.

2011-2012 Centre National d’Etude Spatiale (24k€). Project « Evolution chimique de la matière interstellaire : simulation en laboratoire ». co-PI.

2011-2012 Interdisciplinary funding from "Environnements Planétaires et Origines de la Vie" (8k€). Project « Oligopeptide formation on the primitive Earth : activation, elongation and accumulation ». PI.

2010-2011 Centre National d’Etude Spatiale (20k€). Project « Evolution chimique de la matière interstellaire : simulation en laboratoire ». co-PI.

2010-2011 Interdisciplinary funding from "Environnements Planétaires et Origines de la Vie" (6k€). Project « Oligopeptide formation on the primitive Earth : activation, elongation and accumulation ». co-PI.

2010 Grant for researcher installation from the mayor of Marseille, November 2010.

2008 Best poster award obtained at 15th International Conference on the Origin of Life, International Society for the Study of the Origin of Life (ISSOL), Florence, Italy, August 24-29, 2008.

2008 Grant (500€) obtained for a participation to the 15th International Conference on the Origin of Life, International Society for the Study of the Origin of Life (ISSOL), Florence, Italy, August 24-29, 2008.

2007-2008 post-doctoral grant funded by the "Centre National d’Étude Spatiale".

2006-2007 post-doctoral grant funded by the "National Aeronautics and Space Administration".

2006 Grant (500€) obtained for a participation to the 6th workshop of the European Astrobiology Network Association, Lyon, France, October 16-18, 2006.

Conference Organization

Juin 2016 - Workshop "Apports exogènes et origine de la vie". Journée de la SF2A, 14 au 17 juin 2016 Lyon.

Mai 2016 - Workshop "De la diversité moléculaire du milieu interstellaire à l’homochiralité du vivant". 12 mai 2016 CNES Paris

Septembre 2015 - Convener of the session AB4 "The importance of organic matter evolution from the Interstellar medium to planetary systems" European Planetary Science Congress, september 27th - octobre 02th 2015, La Cité des Congrès, Nantes, France.

April 2015 -Workshop The Astrobiology in present and future missions. April 9th 2015 CNES Paris.

September 2014 - Co-convener of the session LF3 "Planetary analogue samples and environmental simulators" at European Planetary Science Congress 2014, September 07-12 2014, Cascais, Portugal.

March 2013 - Workshop on the evolution of the organic matter in interstellar and interplanetary environments. March 26-27 2013 CNES Paris.

November 2011 -Workshop on photochemistry in terrestrial orbit. November 7th 2011 CNES Paris.

Bibliography

Publications

Pu53. Methanol ice VUV photo-processing : GC-MS analysis of volatile organic compounds. N. Abou Mrad, F. Duvernay, T. Chiavassa and G. Danger. Monthly Notices of the Royal Astronomical Society, 2016, Accepted

Pu52.Thermal formation of hydroxynitriles, precursors of hydroxyacids in astrophysical ice analogs : acetone ((CH3)2C=O) and hydrogen cyanide (HCN) reactivity. A. Fresneau, G. Danger, A. Rimola, F. Duvernay, P. Theulé and T. Chiavassa. Molecular Astrophysics, 2015, 1, 1-12

Pu51. Laboratory Studies Towards Understanding Comets. Murthy S Gudipati, Ninette Abou Mrad, Jürgen Blum, Steven B Charnley, Thierry Chiavassa, Martin A Cordiner, Olivier Mousis, Grégoire Danger, Fabrice Duvernay, Bastian Gundlach, Paul Hartogh, Ulysse Marboeuf, Irakli Simonia, Tsitsino Simonia, Patrice Theulé, Rui Yang. Space Science Review, 2015, 197, 101-150

Pu50. The origin of life : what contribution of chemistry ? G. Danger and R. Pascal, L’Actualité Chimique, 2015, 393_394, 17

Pu49. Formation mechanism of glycolaldehyde and ethylene glycol in astrophysical ices from HCO and CH2OH recombination : an experimental study. T. Butscher, F. Duvernay, P. Theule, G. Danger, Y. Carissan, D. Hagebaum-Reignier and T. Chiavassa. Monthly Notices of the Royal Astronomical Society, 2015, 453, 1587-1596

Pu48. Hydrogenation at low temperatures does not always lead to saturation : the case of HNCO. JA. Noble, P. Theule, E. Congiu, F. Dulieu, M. Bonnin, A. Bassas, F. Duvernay, G. Danger and T. Chiavassa. Astronomy & Astrophysics, 2015, 576, A91

Pu47. Ice chemistry of acetaldehyde reveals competitive reactions in the first step of the Strecker synthesis of alanine : formation of HO–CH(CH3)–NH2 vs. HO–CH(CH3)–CN. A. Fresneau, G. Danger, A. Rimola, F. Duvernay, P. Theulé, and T. Chiavassa. Monthly Notices of the Royal Astronomical Society, 2015, 451, 1649-1660, DOI : 10.1093/mnras/stv1033

Pu46. What are the intermediates that could react in the interstellar ices ? F. Borget, F. Duvernay, G. Danger, P. Theule, JB Bossa, V. Vinogradoff, F. Mispelaer, S. Muller, D. Grote, and T. Chiavassa. Journal of Physical Organic Chemistry, 2015, 28, 163-169, DOI : 10.1002/poc.3380

Pu45. Kinetics of the NH3 and CO2 solid-state reaction at low temperature. JA Noble, P. Theule, F. Duvernay, G. Danger, T. Chiavassa, P. Ghesquiere, T. Mineva and D. Talbi. Physical Chemistry Chemical Physics, 2014, 16, 23604-23615, DOI :

Pu44. Formaldehyde chemistry in cometary ices : the case of HOCH2OH formation. F. Duvernay, A. Rimola, P. Theule, G. Danger, T. Sanchez and T. Chiavassa. Physical Chemistry Chemical Physics, 2014, 16, 24200-24208, DOI :

Pu43. Formaldehyde Chemistry in Cometary Ices : on the Prospective Detection of NH2CH2OH, HOCH2OH, and POM by the on-board ROSINA detection of the Rosetta mission. F. Duvernay, G. Danger, P. Theule, T. Chiavassa, and A. Rimola. The Astrophysical Journal, 2014, 791, 75, DOI : 10.1088/0004-637X/791/2/75

Pu42. Development and optimization of an analytical system for the Volatile organic compounds Analysis coming from the Heating of Interstellar/cometary Ice Analogs , N. Abou Mrad, F. Duvernay, P. Theule, T. Chiavassa and G. Danger. Analytical Chemistry, 2014, DOI : 10.1021/ac501974c

Pu41. Trapping in water – an important prerequisite for complex reactivity in astrophysical ices : the case of acetone (CH3)2C=O and ammonia NH3, A. Fresneau, G. Danger, A. Rimola, P. Theule, F. Duvernay, and T. Chiavassa. Monthly Notices of the Royal Astronomical Society, 2014, DOI : 10.1093/mnras/stu1353

Pu40. Diastereoselectivity in prebiotically relevant 5(4H)-oxazolone-mediated peptide couplings, D. Beaufils, G. Danger, L. Boiteau, JC Rossi, and R. Pascal. Chemical Communications, 2014, 50, 3100-3102. DOI : 10.1039/c3cc49580a

Pu39. Formation of hydroxyacetonitrile (HOCH2CN) and polyoxymethylene (POM)-derivatives in comets from formaldehyde (CH2O) and hydrogen cyanide (HCN) activated by water, G. Danger, A. Rimola, N. Abou Mrad, F. Duvernay, G. Roussin, P. Theule and T. Chiavassa, Physical Chemistry Chemical Physics, 2014, 16, 3360-3370. DOI : 10.1039/C3CP54034K

Pu38. Thermal reactions in interstellar ice : A step towards molecular complexity in the interstellar medium, P. Theule, F. Duvernay, G. Danger, F. Borget, JB Bossa, V. Vinogradoff, F. Mispelaer and T. Chiavassa, advances in Space Research, 2013, 52, 1567-1579. DOI : 10.1016/j.asr.2013.06.034

Pu37. Diffusion measurements of CO, HNCO, H2CO, and NH3 in amorphous water ice, F. Mispelaer, P. Theule, H. Aouididi, J. Noble, F. Duvernay, G. Danger, P. Roubin, O. Morata, T. Hasegawa, and T. Chiavassa, Astronomy & Atrophysics, 2013, 555, A13. DOI : 10.1051/0004-6361/201220691

Pu36. 2-Oxo-2H-chromen-4-yl propionate. Y. Bibila Mayaya Bisseyou, ; A. Abou ; A. Djande ; G. Danger ; R. Kakou-Yao, Rita, Acta crystallographica. Section E, Structure reports online, 2013, 69, o1125-6.

Pu35. Characterization of interstellar/cometary organic residue analogs using very high resolution mass spectrometry, G. Danger, F-R. Orthous-Daunay, P. de Marcellus, P. Modica, V. Vuitton, F. Duvernay, L. Le Sergeant d’Hendecourt, R. Thissen, and T. Chiavassa, Geochimica & Cosmochimica Acta, 2013, 118, 184-201.

Pu34. Kinetic studies on low-temperature solid-state reactions in interstellar ices, P. Theule, F. Duvernay, F. Mispelaer, JB. Bossa, F. Borget, G. Danger, and T. Chiavassa, ECLA : EUROPEAN CONFERENCE ON LABORATORY ASTROPHYSICS, EAS Publications Series, 2013, 58, 363-367, DOI : 10.1051/eas/1258061.

Pu33. Thermal evolution of interstellar ice analogs containing formaldehyde, V. Vinogradoff, F. Duvernay, G. Danger, P. Theule, and T. Chiavassa, ECLA : EUROPEAN CONFERENCE ON LABORATORY ASTROPHYSICS, EAS Publications Series, 2013, 58, 337-341, DOI : 10.1051/eas/1258055.

Pu32. Importance of thermal reactivity for hexamethylenetetramine formation from simulated interstellar ices , V. Vinogradoff, N. Fray, F. Duvernay, G. Briani, G. Danger, H. Cottin, P. Theulé and T. Chiavassa, Astronomy and Astrophysics, 2013, 551, A128, DOI : 10.1051/0004-6361/201220870

Pu31. Formaldehyde and methylamine reactivity in interstellar ice analogues as a source of molecular complexity at low temperature, V. Vinogradoff, F. Duvernay, G. Danger, P. Theulé, F. Borget and T. Chiavassa, Astronomy and Astrophysics, 2013, 549, A40, DOI : 10.1051/0004-6361/201219779

Pu30. hydroxyacetonitrile (HOCH2CN) as a precursor for formylcyanide (CHOCN), ketenimine (CH2CNH), and cyanogen (NCCN) in astrophysical-like conditions, G. Danger, F. Duvernay, P. Theulé, F. Borget, J-C Guillemin, and T. Chiavassa, Astronomy and Astrophysics, 2013, 549, A93, DOI : 10.1051/0004-6361/201219779

Pu29. The thermal reactivity of HCN and NH3 in interstellar ice analogues, J. A. Noble, P. Theule, F. Borget, G. Danger, M. Chomat, F. Duvernay, F. Mispelaer, and T. Chiavassa, Monthly Notices of the Royal Astronomical Society, 2013, 428, 3262-3273, DOI : 10.1093/mnras/sts272

Pu28. 5(4H)-Oxazolones as Intermediates in the Carbodiimide- and Cyanamide- Promoted Peptide Activations in Aqueous Solution, G. Danger, A. Michaut, M. Bucchi, L. Boiteau, J. Canal, R. Plasson, and R. Pascal, Angewandte Chemie International Edition, 2013, 52, 611-614, DOI : 10.1002/anie.201207730 and 10.1002/ange.201207730

Pu27. 2-Oxo-2H-chromen-4-yl 4-meth-oxy-benzoate. A. Akoun, A. Djande, G. Danger, A. Saba, R. Kakou-Yao, Acta crystallographica. Section E, Structure reports online, 2012, 68, o3438-9

Pu26. The desorption of H2CO from interstellar grains analogues, J.A. Noble, P. Theulé, F. Mispelaer, F. Duvernay, G. Danger, E. Congiu, F. Dulieu, and T. Chiavassa, Astronomy and Astrophysics, 2012, 543, A5, DOI : 10.1051/0004-6361/201219437

Pu25. The mechanism of hexamethylenetetramine (HMT) formation in the solid state at low temperature, V. Vinogradoff, A. Rimola, F. Duvernay, G. Danger, P. Theulé and T. Chiavassa, Physical Chemistry Chemical Physics, 2012, 14, 12309-12320, DOI : 10.1039/C2CP41963G

Pu24. Hydroxyacetonitrile (HOCH2CN) formation in astrophysical conditions. Competition with the aminomethanol, a glycine precursor, G. Danger, F. Duvernay, P. Theulé, F. Borget, and T. Chiavassa, The Astrophysical Journal, 2012, 756,11. DOI:10.1088/0004-637X/756/1/11

Pu23. Pathways for the formation and evolution of peptides in prebiotic environments, G. Danger, R. Plasson, and R. Pascal, Chemical Society Reviews, 2012, 41, 5416-5429, DOI : 10.1039/C2CS35064E

Pu22. From interstellar chemistry to prebiotic chemistry : organic matter evolution toward life, G. Danger, and L. Le Sergeant d’Hendecourt, l’Actualité Chimique, 2012, 363.

Pu21. Aminoacetonitrile characterization in astrophysical-like conditions, V. F. Borget, G. Danger, F. Duvernay, M. Chomat, V. Vinogradoff, P. Theulé and T. Chiavassa. Astronomy and Astrophysics, 2012, DOI : 10.1051/0004-6361/201218949

Pu20. Acetaldehyde Solid State Reactivity at Low Temperature : Formation of the Acetaldehyde Ammonia Trimer, V. Vinogradoff, F. Duvernay, M. Farabet, G. Danger, P. Theulé, F. Borget, J.C. Guillemin, and T. Chiavassa. Journal of Physical Chemistry A, 2012, 116, 9, 225-2233, DOI : 10.1021/jp3000653

Pu19. Solid-state methylamine VUV irradiation study using carbon monoxide as H radical scavenger, J-B Bossa, F. Borget, F. Duvernay, G. Danger, P. Theulé, and T. Chiavassa. Australian Journal of Chemistry, 2012, 65, 129-137, DOI : 10.1071/CH11409

Pu18. Activation of Carboxyl Group with Cyanate : Peptide Bond Formation from Dicarboxylic Acids, G. Danger, S. Charlot, L. Boiteau, R. Pascal. Amino Acids, 2012, 42, 6, 2331-2341, DOI : 10.1007/s00726-011-0975-2.

Pu17. Experimental investigation of aminoacetonitrile formation through the Strecker synthesis in astrophysical like conditions : reactivity of methanimine (CH2NH), ammonia (NH3), and hydrogen cyanide (HCN), G. Danger, F. Borget, M. Chomat, F. Duvernay, P. Theulé, J-C Guillemin, L. Le Sergeant d’Hendecourt, T. Chiavassa. Astronomy and Astrophysics, 2011, 525, A30. DOI : 10.1051/0004-6361/201117602.

Pu16. Hydrogenation of solid hydrogen cyanid HCN and methanimine CH2NH at low temperature, P. Theule, F. Borget, F. Mispelaer, G. Danger, F. Duvernay, J. C. Guillemin and T. Chiavassa. Astronomy and Astrophysics, 2011, 534, A64. DOI : 10.1051/0004-6361/201117494

Pu15. New insight on HMT formation mechanism in interstellar ice analogs, V. Vinogradoff, F. Duvernay, G. Danger, P. Theulé, T. Chiavassa. Astronomy and Astrophysics, 2011, 530, A128. DOI : 10.1051/0004-6361/201116688

Pu14. Kinetics of OCN- and HOCN formation from the HNCO + H2O thermal reaction in interstellar ices analogs, P. Theule, F. Duvernay, A. Ilmane, S. Coussan, G. Danger, T. Chiavassa. Astronomy and Astrophysics, 2011, 530, A96. DOI : 10.1051/0004-6361/201016051

Pu13. Photon-induced enantiomeric excesses in initially achiral solid-state “interstellar” molecules, P. de Marcellus, C. Meinert, M. Nuevo, J.-J. Filippi, G. Danger, D.Deboffle, L. Nahon, L. Le Sergeant d’Hendecourt, U. J. Meierhenrich. Astrophysical Journal Letters, 2011, 527, L27. DOI : 10.1088/2041-8205/727/2/L27

Pu12. Experimental investigation of nitrile formation from VUV photochemistry of interstellar ice analogs : acetonitrile and amino acetonitrile, G. Danger, J.-B. Bossa, P. de Marcellus, F. Borget, F. Duvernay, P. Theule, T. Chiavassa, L. d’Hendecourt. Astronomy and Astrophysics, 2011, 525, A30. DOI : 10.1051/0004-6361/201015736

Pu11. Chiral molecule formation in interstellar ice analogs : alpha-aminoethanol NH2CH(CH3)OH, F. Duvernay, V. Dufauret, G. Danger, P. Theulé, F. Borget, T. Chiavassa. Astronomy and Astrophysics, 2010, 523, A79. DOI : 10.1051/0004-6361/201015342

Pu10. An experimental investigation of the evolution of chirality in a potential dynamic peptide system : N terminal epimerization and degradation into diketopiperazine, G. Danger, R. Plasson, R. Pascal. Astrobiology, 2010, 10, 651-662. DOI : 10.1089/ast.2009.0450

Pu9. On-line sample stacking of peptides in capillary electrophoresis for the study of prebiotic reactions between alpha,alpha-dialkylated amino acids and amino acid N-carboxyanhydrides, G. Danger, R. Pascal, H. Cottet. Journal of Chromatography A, 2009, 1216, 5748-5754. DOI : 10.1016/j.chroma.2009.06.010

Pu8. Process improvement in amino acid N-carboxyanhydride synthesis by N-carbamoyl amino acid nitrosation, O. Lagrille, G. Danger, L. Boiteau, J-C Rossi, J. Taillades. Amino Acids, 2009, 36, 341-347. DOI : 10.1007/s00726-008-0090-1

Pu7. Non uniform charge distributions in capillary electrophoresis : theoretical and experimental approach based on Taylor dispersion, G. Danger, R. Pascal, H. Cottet. Electrophoresis, 2008, 29, 4226-4237. DOI : 10.1002/elps.200800128

Pu6. Chiral separation with gradient elution isotachophoresis for future in situ extraterrestrial analysis, G. Danger, D. Ross. Electrophoresis, 2008, 29, 4036-4044. DOI : 10.1002/elps.200700950

Pu5. Development of a Temperature Gradient Focusing Method for in situ Extraterrestrial Biomarker Analysis, G. Danger, D. Ross. Electrophoresis, 2008, 29, 15, 3107-3114. DOI : 10.1002/elps.200700778

Pu4. Temperature gradient focusing with field-amplified continuous sample injection for dual-stage analyte enrichment and separation, M.S. Munson, G. Danger, J. Shackman, D. Ross. Analytical Chemistry, 2007, 79, 6201-6207. DOI : 10.1021/ac070689r

Pu3. Control of the electroosmotic flow in capillary electrophoresis using polyelectrolytes of different charge densities, G. Danger, M. Ramonda, H. Cottet. Electrophoresis, 2007, 28, 6, 925-931. DOI : 10.1002/elps.200600360

Pu2. The peptide formation mediated by cyanate revisited. Conversion of N-carbamoylamino acids into amino acid N-carboxyanhydrides, G. Danger, L. Boiteau, H. Cottet, R. Pascal. Journal of American Chemical Society, 2006, 128, 7412-7413. DOI : 10.1021/ja061339+

Pu1. Dynamic co-evolution of peptides and chemical energetics : a gateway to the emergence of homochirality and the catalytic activity of peptides. A. Commeyras, J. Taillades, H. Collet, L. Boiteau, O. Vandenabeele-Trambouze, R. Pascal, H. Cottet, A. Rousset, L. Garrel, J-C. Rossi, J-P. Biron, O. Lagrille, R. Plasson, E. Souaid, G. Danger, F. Selsis, M. Dobrijevic, H. Martin. Origins of Life and Evolution of Biospheres, 2004, 34, 35-55.

Proceeding and congress abstract published

Pr9. Systems chemistry of alpha-amino acids and peptides , G. Danger, L. Boiteau, JC Rossi and R. Pascal. EPOV 2012 : FROM PLANETS TO LIFE - COLLOQUIUM OF THE CNRS INTERDISCIPLINARY INITIATIVE PLANETARY ENVIRONMENTS AND ORIGINS OF LIFE, Bio Web of Conferences, 2014, 2, 04001. DOI : 10.1051/bioconf/20140204001

Pr8. Analyses of volatile organic compounds and refractory organic residues coming from the heating of interstellar ice analogues, G. Danger, F. Duvernay, P. Theule, F. Borget, P. de Marcellus, FR. Orthous-Daunay, V. Vuitton, LL d’Hendecourt, R. Thissen and T. Chiavassa. EPOV 2012 : FROM PLANETS TO LIFE - COLLOQUIUM OF THE CNRS INTERDISCIPLINARY INITIATIVE PLANETARY ENVIRONMENTS AND ORIGINS OF LIFE, Bio Web of Conferences, 2014, 2, 03004. DOI : 10.1051/bioconf/20140203004

Pr7. From astrochemistry to prebiotic chemistry : an hypothetical approach toward astrobiology, L. Le Sergeant d’Hendecourt, and G. Danger, Proceeding Soci-et-e Francaise d’Astronomie et d’Astrophysique (SF2A) 2012, acceptée.

Pr6. Analytical developments for the search of enantiomeric excess in extraterrestrial environments, G. Danger, D. Ross, Origins of Life and Evolution of Biospheres, 2009, 39, 355-356.

Pr5. V.U.V. irradiation of interstellar ice analogs : a potential source for prebiotic molecules in planetary systems, G. Danger, P. de Marcellus, J.B. Bossa, T. Chiavassa, Z. Djouadi, L. d’Hendecourt, Origins of Life and Evolution of Biospheres, 2009, 39, 231-232.

Pr4. A possible astrophysical pathway to the origin of enantiomeric excess in primitive meteorites : laboratory simulations, P. de Marcellus, G. Danger, L. Nahon, U. Meierhenrich, L. d’Hendecourt, Origins of Life and Evolution of Biospheres, 2009, 39, 287-288.

Pr3. Cyanate and urea as non-conventional activating agents for amino acids. G. Danger, L. Boiteau, H. Cottet, R. Pascal. European Astrobiology Network Association 2006 Meeting EANA – European Astrobiology Network Association 16-18 October 2006 Lyon, France. International Journal of Astrobiology, 2007, 6, 21.

Pr2. An amino-acid based protometabolic system : The primary pump scenario. Implications on the emergence of homochirality. L. Boiteau, G. Danger, R. Pascal, J. Taillades, A. Commeyras, Origins of Life and Evolution of Biospheres, 2006, 36, 267-269.

Pr1. New Synthetic Route to Amino Acids N-carboxyanhydrides from N-carbamoyl Amino Acids : Optimization. Use in Peptide Synthesis. O. Lagrille, G. Danger, L. Boiteau, J. Taillades, A. Commeyras, e-Polymer 2005, n°2, L1358 (http://www.e-polymers.org/paris/data/L1358.pdf). (Proceedings of the IUPAC World Polymer Congress MACRO 2004, 40th International Symposium on Macromolecules, Paris, July 4-9, 2004).

Book Chapter

L1. Molecular origins of life : homochirality as a consequence of the dynamic co-emergence and co-evolution of peptides and chemical energetics. A. Commeyras, J. Taillades, H. Collet, L. Boiteau, O. Vandenabeele-Trambouze, R. Pascal, H. Cottet, L.e Garrel, J-C. Rossi, J-P. Biron, O. Lagrille, R. Plasson, E. Souaid, G. Danger, F. Selsis, M. Dobrijevic. Biological Chirality Elsevier, 2004, pp 49-64.

VULGARIZATION ARTICLE

AV1. De l’astrochimie à l’astrobiologie : pour une approche holistique de l’origine de la vie, L. Le Sergeant d’Hendecourt, G. Danger, L’Astronomie (Société Astronomique de France), Octobre 2012, n°54, p. 20.

Conferences

International conferences

OI22. Volatile organic compounds and organic refractory residues coming from the heating of astrophysical ice analogs : an insight in complex chemistry in astrophysical environments. A prerequisite for astrobiology. G. Danger, N. Abou Mrad, A. Fresneau, F. Duvernay, and T. Chiavassa. COSPAR Symposium, Water and Life in the Universe, Foz do Iguaçu, Brasil, November, 9th-13th, 2015. (invited)

OI21. Habitability : a chemist point of view. G. Danger. Mission to habitable Worlds, COST TD 1308 action, Budapest, Hungary, October, 28th-29th, 2015. (invited)

OI20. Methanol photochemistry as a source of complex organic molecules in cometary environments. N. Abou Mrad, F. Duvernay, T. Chiavassa and G. Danger. European Planetary Science Congress 2015, Nantes, France, September 27- October 02, 2015.

OI19. Trace the evolution of organic matter in interplanetary objects using residue analogues. G. Danger, A. Fresneau, N. Abou Mrad, P. de Marcellus, F. Duvernay, L. Le Sergeant d’Hendecourt , R. Thissen, and T. Chiavassa. European Planetary Science Congress 2015, Nantes, France, September 27- October 02, 2015.

OI18. Follow the evolution of organic matter using laboratory experiments : from volatile organics to organic residues. G. Danger. From interstellar ices to polycyclic aromatic hydrocarbons : A symposium to honor Lou Allamandola’s contributions to the molecular Universe, Annapolis, USA, September 13th-17th, 2015. (invited)

OI17. From astrochemistry to prebiotic chemistry : organic matter evolution toward life ? G. Danger. The first symposium of AbGradE (Astrobiology Graduates in Europe) Pollock Halls campus, Edinburgh, Scotland, October, 9th-10th, 2014.

OI16. Identification of volatile organic compounds coming from the heating of cometary ice analogs- VAHIIA Project. N. Abou Mrad, F. Duvernay, P. Theule, T. Chiavassa, and G. Danger. European Planetary Science Congress 2014 (EPSC 2014), Centro de Congressos do Estoril, Cascais, Portugal, September 7-12, 2014.

OI15. Laboratory analogs for the development of space missions and their data treatments. G. Danger, N. Abou Mrad, A. Fresneau, G. Roussin, F. Duvernay, F. Borget, P. Theulé and T. Chiavassa. European Planetary Science Congress 2014 (EPSC 2014), Centro de Congressos do Estoril, Cascais, Portugal, September 7-12, 2014.

OI14. The AHIIA experimental set-up-for understanding cometary chemistry. G. Danger, F. Duvernay, N. Abou Mrad, A. Fresneau, G. Roussin and T. Chiavassa. European Planetary Science Congress 2014 (EPSC 2014), Centro de Congressos do Estoril, Cascais, Portugal, September 7-12, 2014.

OI13. Formaldehyde chemistry in cometary ices : implication for the Rosetta mission. F. Duvernay, A. Rimola, P. Theulé, G. Danger and T. Chiavassa . European Planetary Science Congress 2014 (EPSC 2014), Centro de Congressos do Estoril, Cascais, Portugal, September 7-12, 2014.

OI12. What do we need for prebiotic chemistry. G. Danger, F. Duvernay,T. Chiavassa, L. d’Hendecourt and R. Pascal. European Planetary Science Congress 2014 (EPSC 2014), Centro de Congressos do Estoril, Cascais, Portugal, September 7-12, 2014.

OI11. From interstellar medium chemistry to prebiotic chemistry : organic matter evolution toward Life ?. G. Danger. 8th Japanese-French Frontiers of Sciences Symposium, Metz, France, January 23-27, 2014. (invited)

OI10. From astrochemistry to prebiotic chemistry an astrobiological point of view. G. Danger. AstroMap Workshop "Origins of organic compounds - steps to Life", Madrid, Spain, October 15-16, 2013.

OI9. Laboratory experiments for understanding the chemical evolution of organic matter in astrophysical ices. G. Danger, F. Duvernay, V. Vinogradoff, P. Theulé, F. Borget and T. Chiavassa. European Planetary Science Congress 2013 (EPSC 2013), University College of London, London, United Kingdom, September 8-13, 2013.

OI8. From astrochemistry to prebiotic chemistry an astrobiological point of view. G. Danger, F. Duvernay, V. Vinogradoff, F. Borget, P. Theulé, T. Chiavassa. European Planetary Science Congress 2013 (EPSC 2013), University College of London, London, United Kingdom, September 8-13, 2013.

OI7. What can we learn from astrochemistry and from prebiotic chemistry in an astrobiological context : the case of amino acids ? G. Danger, F. Duvernay, V. Vinogradoff, F. Borget, P. Theulé, T. Chiavassa. 13th European Astrobiology Network Association (EANA), Szczecin, Poland, July 22-25, 2013.

OI6. An experimental chemical reactor for peptide formation, elongation and accumulation on the Primitive Earth. G. Danger, M. Dobrijevic, F. Selsis, E. Hébrard, L. d’Hendecourt and R. Pascal. 38th COSPAR Scientific Assembly, Bremen, Germany, July 18-25, 2010.

OI5. Epimerization of the N-terminal residue in peptides – The APED model subjected to experimentation. G. Danger, R. Plasson and R. Pascal. European Cooperation in Science and Technology (COST Action CM0703 Meeting), Chembiogenesis 2009, Lake Balaton, Balatonfüred, Hungary, October 23-27, 2009.

OI4. Counterflow gradient electrophoresis : high performance separations with very Simple microfluidic devices. D. Ross, G. Danger, M. Munson, J. Shackman, 32nd International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2008), Baltimore, MD, USA, May 10-16, 2008.

OI3. Cyanate and urea as non-conventional activating agents for amino acids, G. Danger, L. Boiteau, H. Cottet and R. Pascal, 6th workshop of the European Astrobiology Network Association, Lyon, France, October 16-18, 2006.

OI2. New developments in prebiotic chemistry and in capillary electrophoresis. G. Danger, National Institute of Standard and Technology, Analytical Chemistry Division Seminar, Gaithersburg MD, USA, May 23, 2006.

OI1. Novel Strategies for the Control of Electroosmotic Flow in Capillary Electrophoresis. H. Cottet, G. Danger, J. Taillades. MSB’2006 - 20th International Symposium on Micro-Scale Bioseparations, Amsterdam, Netherlands, January 22-26, 2006.

National conferences

ON17. From Astrochemistry to Prebiotic Chemistry : Organic Matter Evolution, 3èmes Journées Méditerranéennes des Jeunes Chercheurs, Montpellier, October 12-14th 2015. (invited)

ON16. Analyse de composés volatils et de résidus organiques provenant du réchauffement d’analogues de glace cométaire, Journées de la SF2A 2015, Université Paul Sabatier, Toulouse, 6 juin 2015. (invited)

ON15. De la chimie du milieu interstellaire à la chimie prébiotique : l’évolution de la matière vers le vivant. G. Danger. Xième journée Biologistes, Chimistes et Physiciens,... aux frontières du vivant : une communauté marseillaise, CINAM, Campus Luminy, Université d’Aix Marseille, Marseille, 01 décembre 2014.

ON14. Quel intérêt ont les apports exogènes pour l’exobiologie. G. Danger. Journée de la Société Française d’Exobiologie, La Baule, France, October, 7-9th, 2014. (invited)

ON13. De la chimie du milieu interstellaire à la chimie prébiotique : l’évolution de la matière vers le vivant. G. Danger. Institut de Chimie de Nice, Nice, France, June, 20th, 2014. (invited)

ON12. De la chimie du milieu interstellaire à la chimie prébiotique : l’évolution de la matière vers le vivant. G. Danger. Centre d’Elaboration de Matériaux et d’Etudes Structurales, Toulouse, France, April, 10th, 2014. (invited)

ON11. Expériences en laboratoire pour la compréhension de l’évolution chimique de la matière organique au sein de glaces astrophysiques. G. Danger. Laboratoire d’Astrophysique de Bordeaux, Bordeaux, France, March, 12th, 2014. (invited)

ON10. De la chimie du milieu interstellaire à la chimie prébiotique : l’évolution de la matière vers le vivant. G. Danger. Centre de Biophysique Moléculaire, Orléans, France, February, 7th, 2014. (invited)

ON9. Analyses des composés organiques volatiles et des résidus organiques réfractaires provenant du réchauffement d’analogues de glace cométaire/interstellaire. G. Danger. Atelier "Analogues" salle de l’espace CNES, Paris, France, December 3th, 2013.

ON8. Apport des expériences en laboratoire pour le spatial. Implication pour le développement de l’orbitrap spatial. G. Danger. Atelier "Orbitrap spatial" salle de l’espace CNES, Paris, France, July 10th, 2013.

ON7. De la chimie du milieu interstellaire à la chimie prébiotique : l’évolution de la matière vers le vivant. G. Danger. Rennes, France, June, 19th, 2013. (invited)

ON6. L’évolution de la matière organique au sein d’environnements astrophysiques : Implication pour l’exobiologie. G. Danger. Atelier Evolution de la matière dans les milieux interstellaires et interplanétaires, Salle de l’espace CNES, Paris, France, March, 26-27, 2013.

ON5. De la chimie du milieu interstellaire à la chimie prébiotique : à la recherche des molécules du vivant. G. Danger. JIREC « la chimie et le vivant » - MIEC « logiciels et ressources libres pour l’enseignement de la chimie », Faculté des sciences d’Orsay, Université Paris-Sud 11, France, May, 24-27, 2011. (invited)

ON4. Un réacteur chimique pour la formation de peptides, leur élongation et leur accumulation sur la Terre primitive. G. Danger, L. Boiteau, R. Pascal. 22ième journée de la chimie SFC-PACA, Toulon, France, March, 11, 2011.

ON3. Evolution de la matière organique du milieu interstellaire à la surface des planètes telluriques. G. Danger, T. Chiavassa, I. Couturier, F. Borget, F. Duvernay, N. Piétri, P. Theule. Rencontres SFE 2010, Biarritz, France, September, 27-30, 2010.

ON2. Nouvelles stratégies de modification de la surface des capillaires en silice pour le contrôle du flux électroosmotique en électrophorèse capillaire. G. Danger, H. Cottet, J. Taillades. 1er Symposium de Chimie et Biologie Analytiques, Montpellier, France, September 26-29, 2005.

ON1. Nouvelle voie de synthèse des N-carboxyanhydrides d’aminoacides à partir de N-carbamoylaminoacides : Optimisation. G. Danger, O. Lagrille, L. Boiteau, J. Taillades, A. Commeyras. 13ième journée Chimie Grand Sud Ouest, Pau, France, November 28, 2003.